Although further work and validation is needed, the TG approach provides a novel, and promising method to diagnose glaucoma, a major cause of ocular morbidity.Kiage, Dan Kherani, Irfan N. Poor quality photographs can severely limit the ability of TG assessment to diagnose optic nerve damage and glaucoma. There was moderate agreement between the ability to diagnose glaucoma using TG relative to clinical slit lamp examination. A positive TG diagnosis of glaucoma carried a 77.5% positive predictive value, and a negative TG diagnosis carried an 82.2% negative predicative value relative to the clinical slit lamp examination. The use of FDT to detect glaucoma in the presence of disc damage (VCDR 0.7) showed substantial agreement (κ statistic of 0.84 and 95% CI 0.79-0.90). While the identification of individual optic nerve factors showed either fair or moderate agreement, the ability to diagnose glaucoma based on the overall assessment showed moderate agreement (Kappa κ statistic 0.55% and 95% confidence interval CI: 0.48-0.62).
Of 309 TG assessment photos, 74 (24%) were deemed unreadable due to media opacities, patient cooperation, and unsatisfactory photographic technique. Identifying potential.Reed, Robyn C Kim, Sara Farquharson, Kara Astion, Michael LCompetency assessment is critical for laboratory operations and is mandated by the Clinical Laboratory Improvement Amendments of 1988. Time to ethics and regulatory approval may not limit site inclusion if compensated by rapid recruitment. Population availability and time to ethics and regulatory approvals influence recruitment therefore accurate feasibility assessments are critical to site selection. Sites took longer to submit final reports, overall median of 28 (7 to 91) days, ranging from 7 days (Australia) to 67 (23 to 103) days (Europe). Median days for initial SAE submission to sponsor was 6 (2 to 20), ranging from 4 (2 to 18) (Latin America) to 24 (5 to 46) days (Australia). Median days to EDC was 7 (3 to 16), ranging from 3 (1 to 16) (Asia) to 13 (8 to 14) days (North America). The converse was true in Latin America where despite ethics, regulatory and contractual delays, recruitment was 104% of predicted.
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